GPCR Signaling
Regulation of G protein-coupled receptor (GPCR) signaling by Regulator of G protein signaling (RGS) proteins. RGS proteins function as GTPase-activating proteins for specific Ga subunits and thereby function to terminate G protein signaling by GPCRs.
mRNA splicing
Diagram of the complex splicing of human RGS6 pre-mRNA to generate 36 splice variants. Two primary transcripts encode the 5′-splice forms of RGS6; the AUG-1 start site produces a transcript that encodes the RGS6L forms of the protein while the AUG-2 start site produces a transcript that encodes the RGS6S forms of the protein. Retention or removal of exon 13 (first pink square) generates transcripts that encode for proteins containing or lacking a complete GGL domain, respectively. 3′-splicing generates transcripts containing seven distinct 3′ exons. RGS6 α and β transcripts exist in two forms that arise from either the retention (α1 and β1) or removal (α2 and β2) of exon 18 (second pink square). Image adapted from Chatterjee et al, J. Biol. Chem. 2003.
RGS protein model
Structural model of RGS6La2 in complex with Gb5 based upon the known structure of the RGS9-Gb5 complex (PDB ID: 2PBI). Model was generated by Dr. Koland (Univ. of Iowa).
RGS patho
Schematic outlining identified physiological and pathophysiological functions of RGS6.
